Arginine and nitric oxide (NO) metabolism in sepsis; effects of L-arginine supplementation on whole body and splanchnic metabolism and microcirculation in severely septic patients.

ovartis Consumer Health - R&D Nutrition.0 个研究点目标入组 16 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

Luiking, Y. C., Poeze, M., Dejong, C. H., Ramsay, G. & Deutz, N. E. (2004) Sepsis: an arginine deficiency state? Crit Care Med 32: 2135-2145.
2. Bruins, M. J., Soeters, P. B., Lamers, W. H. & Deutz, N. E. (2002) L-arginine supplementation in pigs decreases liver protein turnover and increases hindquarter protein turnover both during and after endotoxemia. Am J Clin Nutr 75: 1031-1044.
3. Bruins, M. J., Luiking, Y. C., Soeters, P. B., Lamers, W. H., Akkermans, L. M. & Deutz, N. E. (2004) Effects of long-term intravenous and intragastric L-arginine intervention on jejunal motility and visceral nitric oxide production in the hyperdynamic compensated endotoxaemic pig. Neurogastroenterol Motil 16: 819-828.

•1. Shock due to any cause other than sepsis (e.g. drug reaction or drug overdose, pulmonary embolus, burn injury, severe blood loss etc.);
•2. Prolonged or high dose corticosteroid use;

发起方

ovartis Consumer Health - R&D Nutrition.