Relevance of endogenous conditioned pain modulation (CPM) for hyperalgesia following a first-degree burn-injury in healthy volunteers.
Not Applicable
Recruiting
- Conditions
- Endogenous pain inhibition and sensitization mechanisms leading to acute and chronic painhealthy volunteers
- Registration Number
- DRKS00009252
- Lead Sponsor
- niversitätsklinikum MünsterKlinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 84
Inclusion Criteria
healthy volunteers
Exclusion Criteria
- intake of analgesics or psychopharmaca
- chronic pain condition
- neurological condition
- diabetes mellitus
- hypertension
- pregnancy
- intake of oral contraception
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation between Conditioned Pain Modulation Effect and the magnitude of secondary hyperalgesia before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury<br><br>Measurement of Conditioned Pain Modulation Effect: painful stimulation with contact heat before, during and after immersing their contralateral hand in painful cold water (conditioned stimulation). The degree by which the conditioning stimulation affects the contact heat stimulus reflects pain inhibition. <br><br>Measurement of secondary hyperalgesia: an area of augmented pain sensitivity, which is mediated by the central nervous system, develops surrounding the burn. This area reflects central sensitization.
- Secondary Outcome Measures
Name Time Method Correlation between Conditioned Pain Modulation and thermal and mechanical thresholds and mechanical pain sensitivity before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury; Differences across gender and menstrual cycle (folicular phase, luteal phase) in women regarding the above mentioned parameters before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury; correlation between sex hormone levels (estrogene, progesterone, testosterone, FSH, LH) and the above mentioned parameters before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury<br>