Effect of Dynamic Hyperinflation on Pulmonary Hemodynamics and Right Ventricular function in Chronic Obstructive Pulmonary Disease

Completed

Conditions: COPD
emphysema
10038716

Registration Number: NL-OMON34856

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

COPD GOLD 2-4
Suspected pulmonary hypertension.
Patients with progressive complains and/or unexplained complains with stable lungfunction or cardiovascular limitations during exercise test in who an RHC is clinical indicated

Exclusion Criteria

History of systemic hypertension
History of left sided cardiac failure
Signs of left ventricular dysfunction and/or valvular disease on Doppler echocardiography made prior to inclusion.
Neuromuscular disorders
COPD-Exacerbations during last 4 weeks

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Do COPD patients with dynamic hyperinflation have a more impaired response of<br /><br>stroke volume and cardiac output at exercise than COPD patients with a similar<br /><br>GOLD classification without dynamic hyperinflation?<br /><br>- SV using direct Fick method at every level of exercise<br /><br>- Inspiratory capacity (IC)<br /><br><br /><br>What is the effect of dynamic hyperinflation on right and left ventricular<br /><br>function in COPD?<br /><br>-RV pressure/volume curves derived from RHC (pressure) and cMRI (volumes)<br /><br><br /><br><br /><br>What is the effect of dynamic hyperinflation on systemic oxygen delivery and<br /><br>extraction?<br /><br>-Arterial and venous blood samples</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Does the reduction of dynamic hyperinflation in COPD by Heliox (Helium-Oxygen)<br /><br>inhalation lead to afterload reduction of the right ventricle and by that to<br /><br>improvement of the cardiac output augmentation during exercise?<br /><br><br /><br>- SV, IC and blood samples during Heliox test<br /><br>- Pressure measuremens of RHC<br /><br><br /><br><br /><br>What is the influence of dynamic hyperinflation and stroke volume impairment on<br /><br>the outcomes of the rehabilitation program.<br /><br><br /><br>- Lung function, exercise capacity, quality of life scores during and after<br /><br>rehabilitation program. </p><br>