Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

• Conditions: Pulmonary Disease, Chronic Obstructive

• Registration Number: NCT03230617
• Lead Sponsor: Assiut University

Brief Summary

Chronic obstructive pulmonary disease is a common respiratory condition that is characterized by inflammation of the large and small peripheral airways , the alveoli and adjacent capillary networks. Severe airflow obstruction that imposes a significant load on the respiratory system is a major manifestation of Chronic obstructive pulmonary disease. The reduced expiratory airflow also causes air trapping at the end of expiration , producing alveolar pressure that are higher than atmospheric pressure before the next breath. This condition is intrinsic positive end-expiratory pressure .

Detailed Description

Not available

Study Timeline

• Status Verified: 2017-07
• Study First Submitted: 2017-07-24
• Study First Submitted QC: 2017-07-24
• Last Update Submitted: 2017-07-25
• Study First Posted: 2017-07-26
• Last Update Posted: 2017-07-27
• Study Start: 2017-09-01
• Primary Completion: 2018-09-01
• Study Completion: 2018-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• patient with acute exacerbation of Chronic obstructive pulmonary disease and respiratory failure who are intubated and mechanically ventilated.

Exclusion Criteria

• patient with neuromuscular diseases.
• patient with pulmonary vascular diseases e.g pulmonary embolism.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The duration of mechanical ventilation	1 month

Trial Locations

Locations (1)

Assiut University; 🇪🇬 Assiut, Egypt