The effect of vitamin D3 supplementation on AKI risk in multiple trauma patients admitted to ICU with elevated CPK level

Not Applicable

Conditions: Acute kidney injury (AKI) refers to an abrupt decrease in kidney function, resulting in the retention of urea and other nitrogenous waste products and in the dysregulation of extracellular volume and electrolytes.
Acute kidney injury
N.17.9

Registration Number: IRCT20120703010178N23

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 30

Inclusion Criteria

patients over 18
patients with at least two distinct injuries who were diagnosed with multiple trauma
Serum creatinine phosphate level higher than or equal to 5 times normal, from admission to the intensive care unit up to 48 hours later

Exclusion Criteria

Patients with a recent history of myocardial infarction (within one week before the trauma)
pregnancy or lactation,
patients with direct kidney trauma
high serum vitamin D3 levels
patients who received more than 2000I.U of vitamin D3 per day during the past week,
total calcium level above 9 mg/dl or phosphate level above 6 mg/dl at the time of admission,
history of organ transplantation or long-term use of immunosuppressive drugs,
patients with a history of diseases related to vitamin D3 levels, such as primary parathyroid, metabolic bone disease, or acute renal failure

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of acute kidney injurie. Timepoint: within 2 weeks if ICU admission. Method of measurement: laboratory results of Serum creatinine; urine output.;Serum creatine phosphokinase level. Timepoint: Daily from the ICU admission date up to either reaching normal level or 14 days. Method of measurement: Serum CPK level laboratory measurement kits.

Secondary Outcome Measures

Name	Time	Method
Follow up death for 28 days. Timepoint: since admitted it the ICU we follow up daily up to 28 days. Method of measurement: dead or alive before the 28 days follow up.