A study to compare the effect of betamethasone oral mini-pulse therapy and oral azathioprine in progressive non-segmental vitiligo
Not Applicable
- Conditions
- Health Condition 1: null- vitiligo
- Registration Number
- CTRI/2013/10/004089
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Patients fulfilling all these criteria will be included in the study
•Age >18yrs
•Non segmental vitiligo
•Involvement of >2% of body surface area
•(a) Progressive disease of any duration (having >5 new lesions in last 1 month or >15 new lesions in last 3 months)
Or
(b) Disease onset within last one year and continuing to have new lesions
Exclusion Criteria
Patients will be excluded from the study if they have
•Segmental vitiligo
•Focal vitiligo
•Pure mucosal vitiligo
•Stable disease
•Pregnancy, lactation
•Concomitant infectious diseases, uncontrolled diabetes mellitus or hypertension
•Active liver disease
•Patients who have taken systemic corticosteroid or other immunosupressants in last two months, or that of topical in last one month.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -number of new lesions compared to previous visit. <br/ ><br> -change in size of existing lesion <br/ ><br> -extent of re-pigmentation, color match <br/ ><br> -drug related side effects if any <br/ ><br> -vitiligo impact scale <br/ ><br>Timepoint: monthly in first 6 months then 2 monthly
- Secondary Outcome Measures
Name Time Method drug related side effects if any <br/ ><br> -vitiligo impact scale <br/ ><br>Timepoint: monthly in first 6 mnths then 2 monthly