Effect of pregabalin premedication on emergence agitation in pediatric infraumblical abdominal surgery after sevoflurane anesthesia , double blinded, randomized placebo control study.
Trial Snapshot
- Phase
- Unknown
- Status
- Not yet recruiting
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Oral pregabalin premedication is effective in Emeregence Agitation after Sevoflurane anesthesia
Study Overview
Brief Summary
Emergence agitation (EA) is a temporary condition that occurs while awaking from general anesthesia.
Sevoflurane is very valuable for induction and continuation of anesthesia in pediatrics, but it is correlated with increased ratio of EA.
Medications used to prevent EA may have unwanted adverse effects such as vomiting and delayed recovery.
Pregabalin belongs to gabapentinoid compounds with anticonvulsant, pain killing, and antianxi-ety activity. The target of this study is to define the influence of pregabalin premedication in pe-
diatrics on EA after sevoflurane anesthesia.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 4.00 Year(s) to 12.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •1 Age: 4-12years 2 mASA physical status 3 Child undergoing Infraumblical Abdominal surgery.
Exclusion Criteria
- •1 Patient’s parent’s refusal 2 History of developmental delay or mental retardation,which will make observational pain intensity assessment difficult 3 Anatomical abnormalities 4 Bleeding diathesis 5 Coagulation disorder 6 History of renal,hepatic,cardiac disorder upper or lower infection or any neurological abnormalities 7 Emergency cases 8 Cerebral palsy.
Outcomes
Primary Outcomes
Oral pregabalin premedication is effective in Emeregence Agitation after Sevoflurane anesthesia
Time Frame: Day 0 at baseline
in Infraumblical abdominal surgeries.
Time Frame: Day 0 at baseline
Secondary Outcomes
No secondary outcomes reported
Investigators
Dr Himanshi
All India institute of medical sciences , Raipur