Does a single oral dose of dexamethasone after successful emergency department treatment of migraine reduce the incidence or severity of rebound headache within 48 hours?
Phase 4
Completed
- Conditions
- MigraineNeurological - Other neurological disorders
- Registration Number
- ACTRN12605000034639
- Lead Sponsor
- The Joseph Epstein Centre for Emergency Medicine Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 76
Inclusion Criteria
Consenting adult patients with physician-diagnosed migraine treated in the ED who are willing and able to be contacted between 48-72 hours after discharge for follow-up.
Exclusion Criteria
Failure to consent. Pregnancy. Allergy to study medication. Findings inconsistent with migraine. Patients requiring hospital admission for further investigation and treatment. Patients with active peptic ulcer disease. Patients with Type 1 diabetes. Patients taking corticosteroids for another condition within 7 days. Active systemic fungal infection. Patients previously enrolled in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of patients who were discharged pain free that have a recurrence of headache within 48 hours[48 hours];Proportion of patients who were not pain free at discharge whose headache is worse or unchanged within 48 hours[48 hours]
- Secondary Outcome Measures
Name Time Method Comparison of headache severity.[At Hospital Discharge];Analgesia/ health service use[48 hours];Adverse events and return to normal functioning between the groups.[48 hours]