CBD-Microglia PET Study
- Conditions
- HealthyCBD
- Interventions
- Registration Number
- NCT04398719
- Lead Sponsor
- Yale University
- Brief Summary
This study aims to examine the effect of cannabidiol (CBD) pre-treatment on brain microglial activation in healthy human subjects. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects.
- Detailed Description
This study aims to examine the effect of cannabidiol (CBD), pre-treatment, as Epidiolex, on brain microglial activation in healthy human subjects using \[11C\]PBR28 PET imaging. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects. Lastly, this research study will also examine the relationship between brain microglial activation and central pain sensitization with CBD pre-treatment.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 15
- Men and women aged 18- 55 years
- No significant medical or neurological illness
- No implanted metal devices that may pose a risk during MRI scanning
- Within the annual permissible radiation exposure
- Able to provide written informed consent.
- Current use of any medications
- Presence of metal in the body
- Pregnancy or lactation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CBD [11C]PBR28 - CBD Low-dose lipopolysaccharide - Placebo [11C]PBR28 - Placebo Intradermal Capsaicin - CBD Intradermal Capsaicin - Placebo Low-dose lipopolysaccharide -
- Primary Outcome Measures
Name Time Method Microglial activation using [11C]PBR28 PET imaging 10 Days Difference in microglial activation (\[11C\]PBR28 VT levels) between the 2 groups (e.g., CBD vs. placebo)
- Secondary Outcome Measures
Name Time Method Capsaicin-induced hyperalgesia 10 Days Difference in capsaicin-induced hyperalgesia between the 2 groups (e.g., CBD vs. placebo)
Trial Locations
- Locations (1)
Connecticut Mental Health Center
🇺🇸New Haven, Connecticut, United States