Incidence of Postthoracotomy Pain Following General Anesthesia: A Comparison Between TIVA and Inhalation Anesthesia

• Conditions: Lung Cancer; Neoplasms, Lung
• Interventions: Drug: propofol, remifentanil, sevoflurane

• Registration Number: NCT00935571
• Lead Sponsor: Asan Medical Center

Brief Summary

The purpose of this study is to evaluate the incidence of postthoracotomy pain between total intravenous anesthesia (TIVA)and inhalation anesthesia after lung surgery.

Detailed Description

Thoracotomy is one of the most painful surgical incisions. It has been shown that 5-80% of patients still suffer from thoracic pain 2-3 months after surgery and the international association for the study of pain (IASP) defines postthoracotomy pain syndrome (PTTS)as pain that recurs or persists at least 2 months after surgical procedure. Previous reports have shown that the incidence of PTTS varies according to preoperative pain, pain intensity, sex, and types of procedure. However, little is known about the effect of the type of anesthesia to postthoracotomy pain.

Study Timeline

• Study Start: 2007-10
• Primary Completion: 2009-06
• Status Verified: 2009-07
• Study First Submitted: 2009-07-08
• Study First Submitted QC: 2009-07-08
• Last Update Submitted: 2009-07-08
• Study First Posted: 2009-07-09
• Last Update Posted: 2009-07-09
• Study Completion: 2009-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• patients undergo elective thoracotomy of lung surgery

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Exclusion Criteria

• emergency operation age under 18 years patients with unstable hemodynamics

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group I, Group II	propofol, remifentanil, sevoflurane	Group I: anesthetized with TIVA (Propofol + Remifentanil) Group II: anesthetized with inhalation (sevoflurane)

Primary Outcome Measures

Name	Time	Method
Incidence of pain	3 and 6 months later after operation

Secondary Outcome Measures

Name	Time	Method
pain characters	3 and 6 months later after operation

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Center; 🇰🇷 Seoul, Korea, Republic of