Late Biomarkers in Adult Survivors After Out-of-hospital Cardiac Arrest
- Conditions
- Cardiac Arrest, Out-Of-Hospital
- Registration Number
- NCT06587763
- Lead Sponsor
- Region Skane
- Brief Summary
Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by authorised medical personnel. Plasma, serum and PAX-RNA will be collected (ca 15 ml in total), processed and frozen for analysis after trial completion.
- Detailed Description
Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by authorised medical personnel. Plasma, serum and PAX-RNA will be collected (ca 15 ml in total), processed and frozen for analysis after trial completion.
Samples will be analysed in batch for biomarkers of brain injury, inflammation etc.
Primary outcome is functional outcome (modified Rankin Scale 4-6) at six months after cardiac arrest.
Secondary outcomes are neurocognitive function according to the Montreal Cognitive Assessment (MoCA), Symbol Digits Modalities Test (SDMT).
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 400
- Survivors of out-of-cardiac arrest who participate in the extended follow-up study of the STEPCARE trial at selected sites only
- Patients not participating in the extended follow-up at participating sites
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Functional outcome 6 months Modified Rankin Scale 4-6
- Secondary Outcome Measures
Name Time Method Neurocognitive outcomes 6 months Symbol Digit Modalities Test
Trial Locations
- Locations (3)
Helsingborgs Hospital
🇸🇪Helsingborg, Sweden
Skåne university hospital
🇸🇪Lund, Sweden
Skåne University Hospital
🇸🇪Malmö, Sweden