Late Biomarkers in Adult Survivors After Out-of-hospital Cardiac Arrest
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- Region Skane
- 入组人数
- 400
- 试验地点
- 3
- 主要终点
- Functional outcome
研究概览
简要总结
Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by authorised medical personnel. Plasma, serum and PAX-RNA will be collected (ca 15 ml in total), processed and frozen for analysis after trial completion.
详细描述
Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by authorised medical personnel. Plasma, serum and PAX-RNA will be collected (ca 15 ml in total), processed and frozen for analysis after trial completion.
Samples will be analysed in batch for biomarkers of brain injury, inflammation etc.
Primary outcome is functional outcome (modified Rankin Scale 4-6) at six months after cardiac arrest.
Secondary outcomes are neurocognitive function according to the Montreal Cognitive Assessment (MoCA), Symbol Digits Modalities Test (SDMT).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Survivors of out-of-cardiac arrest who participate in the extended follow-up study of the STEPCARE trial at selected sites only
排除标准
- •Patients not participating in the extended follow-up at participating sites
结局指标
主要结局
Functional outcome
时间窗: 6 months
Modified Rankin Scale 4-6
次要结局
- Neurocognitive outcomes(6 months)