The effect of pentoxifylline on improving of anemia in hemodialysis patients
- Conditions
- Anemia in patients with hemodialysis.Chronic kidney disease
- Registration Number
- IRCT2014042117380N1
- Lead Sponsor
- Vice-chancellor for research -Shahid Sadoughi University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
all patients with chronic hemodialysis who had hemoglobin level less than 11 gr/dL despite receiving 100-200 IU/Kg/W recombinant erythropoietin at least 3 months before starting the study.
Exclusion criteria: age< 18 years old; pregnancy; past history of allergy or intolerance to Pentoxiphyllin; the use of hemodialysis catheter in a recent month; paients with active ulcer disease or dyspepsia; major surgery within 3 months ago; blood transfusion in past month; history of myocardial infarction, stroke and brain hemorrhage in 3 months ago; suboptimal dialysis in recent 2 months ( KT/V < 1.2 ); PTH > 300 pg/mL; Iron deficiency ( ferritin level < 100 µg/L or TIBC < 20% ); any hospitalization in past month ; the previous history of hematological problems such as hemoglobinopathies.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean changes in hemoglobin concentrations. Timepoint: 4 times, monthly. Method of measurement: with CBC.
- Secondary Outcome Measures
Name Time Method Erythrocyte Sedimentation Rate. Timepoint: each 2 months. Method of measurement: with lab tests.;C Reactive Protein. Timepoint: each 2 months. Method of measurement: with lab tests.