The CArdiac Imaging RegistrY Study: Computed ToMogrAphy for Risk Stratification and Diagnostic Safety
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Survival
研究概览
简要总结
In this prospective longitudinal observational investigator-led single centre cohort study we will include patients undergoing cardio-CT for clinical reasons, to evaluate the role of cardio-CT terms of its diagnostic and prognostic value, as well as risk-benefit ratio.
Particular aims include:
-
To determine the prevalence of CAD for age, gender, ethnicity relative to established risk models
-
To determine associations between CAD severity and plaque type and:
-
with traditional risk factors (arterial hypertension, diabetes, hypercholesterolemia, smoking)
-
blood markers of increased cardiovascular risk
-
To determine predictive associations of between CAD with outcome (endpoint definitions in appendix)
-
To determine the risk-benefit ratio (number of subsequent interventions, complications, radiation exposure, late onset of cancer diseases, etc).
详细描述
Particular aims include:
-
To determine the prevalence of CAD for age, gender, ethnicity relative to established risk models
-
To determine associations between CAD severity and plaque type and:
-
with traditional risk factors (arterial hypertension, diabetes, hypercholesterolemia, smoking)
-
blood markers of increased cardiovascular risk
-
To determine predictive associations of between CAD with outcome (endpoint definitions in appendix)
-
To determine the risk-benefit ratio (number of subsequent interventions, complications, radiation exposure, late onset of cancer diseases, etc).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults (=/>18 years of age)
- •Able to provide informed consent
- •Clinical indication for cardio-CT in line with the latest clinical guidelines
排除标准
- •standard contraindications to CT (in line with local roles and guidelines - please see Appendix)
- •known allergy to iodinated contrast agent
- •suspected acute kidney injury
- •unstable hemodynamic status or arrhythmias
- •suspected acute coronary syndrome
- •manifest thyrotoxicosis
结局指标
主要结局
Survival
时间窗: 5 year
number of deaths
Survival
时间窗: 2 year
number of deaths
次要结局
未报告次要终点
研究者
Valentina Puentmann
Clinical professor
Johann Wolfgang Goethe University Hospital