Identification of the Pathophysiological Substrate of Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Completed
- Conditions
- atrial fibrillationheart rhythm disturbances10007521
- Registration Number
- NL-OMON32366
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Patients with atrial fibrillation selected to undergo surgical treatment of AF alone or in combination with valvular and/or coronairy surgery.
History of AF (both paroxysmal and chronic AF)
Age between 18 and 80 years
Patient did give informed consent in writing
Exclusion Criteria
Previous thoracic surgery (epicardial measurements not possible due to adhesions)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Sinus rhythm 6 and 12 month after treatment.<br /><br>Mortality (in hospital, 6 month and 12 month).<br /><br>Degree of fibrosis from the left atrial appendage.<br /><br>Atrial fibrillation cycle length from different atrial locations.<br /><br>Degree of electrogram fragmentation during AF from different locations of the<br /><br>right and left atria and the pulmonary veins.<br /><br>Conduction characteristics from different locations of the right and left atria<br /><br>and the pulmonary veins.<br /><br>Electrophysiological exit and entrance block after pulmonary vein ablation.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Morbidity including CVA, TIA<br /><br>Hospital length of stay<br /><br>Use of antiarrhythmic agents<br /><br>Preoperative duration of AF.<br /><br>Preoperative echocardiographic parameters such as atrial dimensions, left<br /><br>ventricular dimensions and ejection fraction, valvular characteristics.</p><br>