COVID-19 and ICU-acquired MDR Bacteria

Completed

• Conditions: Sars-CoV2; Critical Illness

• Registration Number: NCT04378842
• Lead Sponsor: University Hospital, Lille

Brief Summary

This multicenter before-after study aimed to determine the impact of infection related to SARS-CoV-2 on the incidence of ICU-acquired multidrug resistant (MDR) bacteria.

Detailed Description

Multicenter observational before-after study, aiming to determine the impact of infection related to SARS-CoV-2 on the incidence of ICU-acquired colonization and infection related to MDR bacteria.

Study Timeline

• Study First Submitted: 2020-05-05
• Study First Submitted QC: 2020-05-05
• Study First Posted: 2020-05-07
• Study Start: 2020-05-18
• Primary Completion: 2021-07-26
• Study Completion: 2021-07-26
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-04
• Last Update Posted: 2022-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 368

Inclusion Criteria

• Expected ICU stay > 48 hours
• Rectal and nasal BMR screening performed < 48 hours after admission to ICU

Exclusion Criteria

• Patients aged < 18 years Refusal to take part in the study ICU-stay < 48 hours At least a second rectal and nasal BMR screening was not performed prior to ICU discharge (a posteriori exclusion criterion).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cumulative incidence of ICU-acquired colonization related multidrug resistant bacteria	from D3 until day 28 after ICU admission	percentage of patients with ICU acquired MDR bacteria colonization

Secondary Outcome Measures

Name	Time	Method
mortality	from D1 until day 28 after ICU admission	death in the ICU
Cumulative incidence of ICU-acquired infection related to multidrug resistant bacteria	from D3 until day 28 after ICU admission	percentage of patients with ICU acquired MDR bacteria infection
Mechanical ventilation duration	from D1 until day 28 after ICU admission	the number of days Under mechanical ventilation
length of stay in intensive care unit	from D1 until day 28 after ICU admission	the number of days of hospitalization in the ICU

Trial Locations

Locations (7)

Chu Amiens Picardie; 🇫🇷 Amiens, France

Ch Bethune; 🇫🇷 Béthune, France

Grand Hopital de L'Est Francilien; 🇫🇷 Jossigny, France

CH LENS; 🇫🇷 Lens, France

Hospices Civils de Lyon; 🇫🇷 Lyon, France

Hospices Civils de Lyon (Pierre Bénite,Edouard Herriot, La Croix Rousse); 🇫🇷 Lyon, France

Hôpital Roger Salengro, ICU, CHU Lille; 🇫🇷 Lille, France