Comparing the immune response between kidney transplant recipients with standard immunosuppressive regimen vs mycophenolic acid sparing regimen after extended primary series of two doses of Chadox-1 and single dose of BNT-162b2.
Recruiting
- Conditions
- immunological response after the booster dose of vaccine is given.covid vaccinekidney transplantBNT162b2
- Registration Number
- TCTR20220402001
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 113
Inclusion Criteria
post kidney transplant > 6 months
post ChAdOx-1 2 dosesage 18-70 YO
Exclusion Criteria
recently renal graft rejection
active CMV, BK viremia, infection
active malignancy
pregnancy and breast feeding
past COVID infection
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method anti SARS-CoV2 S antibody 4 weeks Elecsys, by Cobas e 411 analyzer; Roche Diagnostics, Basel, Switzerland
- Secondary Outcome Measures
Name Time Method anti HLA antibody 4 weeks PRA beads