Antidepressant Efficacy of Prefrontal Transcranial Magnetic Stimulation Monotherapy in Non-drug-responsive Major Depression: a Randomized Case-control Study

Phase 3

Recruiting

• Conditions: A treatment option for Medication-resistant depression

• Registration Number: JPRN-UMIN000020892
• Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-04
• Study Completion: 2018-12-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

Patients with schizophrenia, organic mental disorder and major physical illness; with brain implants or cardiac pacemakers; pregnancy; or who having strong suicidal risk

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the changing of HDRS-17 (week-2 vs. baseline) in response to the 2-week prefrontal brain stimulation

Secondary Outcome Measures

Name	Time	Method
Computerized rACC-engaging cognitive tasj(RECT); EEG; Maudsley Staging method for refractoriness; response rate; the changing of HDRS-17 of the 12-week follow-up after the treatment (week-14 vs. baseline) in response to the 2-week brain stimulation; Young mania Rating scale; Clinical Global Index; Depression and somatic symptoms; Life stress scale; the comparison for localization between" 5 cm rule" and MRI neuro-navigation.