A Comparative study of two different Dexmedetomidine dosages in attenuation of hemodynamic response during extubation

The present study is a Prospective, Randomized and Comparative study done after approval of Institutional Ethics Committee in patients satisfying all inclusion and exclusion Criteria planned for short surgeries under GA.Patient will be kept nil per orally before surgery. An IV line will be secured. Patient will be connected to multi parameter monitor for recording heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), SPO2.The patient will be premedicated with IV glycopyrrolate 0.01 mg/kg, IV midazolam 0.05mg/Kg and IV Ondansetron 0.08 mg/Kg. Induction with Inj propofol 1-2 mg/Kg followed by IV vecuronium 0.1 mg/Kg for muscle relaxation and cuffed endotracheal tube will be inserted smoothly. Intra-operatively patient’s HR, SBP, DBP, MAP and SPO2 will be monitored. Patients will be extubated by the anaesthesiologist when the following criteria are fulfilled: sustained head lift for 5 seconds, sustained hand grip for 5 seconds, and adequate level of consciousness. HR, SBP, DBP, MAP, and SPO2 readings baseline (just prior to test drug infusion), 1, 3, 5, 7 and 10 minute during infusion, following reversal administration, just before extubation, after-extubation 1, 3, 5, 7, 10, 15, 30 minute were recorded.