A clinical trial to study the impact of supervised weight loss secondary to diet and lifestyle modifications (including yoga) on fat distribution (subcutaneous and visceral fat, which are meaured using CT scan) and insulin resistance (precursor of type 2 diabetes) in adult Indian obese patients

Completed

• Conditions: Obesity

• Registration Number: CTRI/2015/05/005750
• Lead Sponsor: All India Institute of Medical Sciences

Brief Summary

This study is an interventional trial to evaluate the impact of



diet and lifestyle modifications on weight, insulin resistance



and fat distribution of adult Indian obese patients. On initial



evaluation, a detailed history was taken and the following



parameters were noted-



• BMI in kg/m2



• Waist circumference in centimeters



• OGTT in mg/dl



• Fasting insulin levels



• Fat distribution- subcutaneous, visceral and total at L4-



L5 disc level using a single cut section CT scan.



The patients are given dietary consultation by an expert



dietician and followed up regularly. They are also taught



yoga in our hospital for 1 week under the department of



physiology by a trained yoga teacher and then asked to



continue practising at home. These patients are followed up



for 3 months and the above parameters are again noted.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01-01
• Last Update Posted: 2015-03-20

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patients with obesity, defined as Body Mass Index > 30.

Exclusion Criteria

• 1.Patients < 18 years and >60years.
• 2.Patients with known hypothalamic-pituitary & genetic causes of obesity 3.Patients who refuse consent for the study 4.Patients, who are on medications that can affect weight such as thyroxine, steroids.
• 5.Patients who do not fit into our CT machine.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
• To study the impact of supervised dietary changes and lifestyle modifications on weight loss (in kgs over 3 months) in obese Indian adults.	3 months
• To study the body fat distribution ( by single cut section of abdomen at L4-L5 disc level) and insulin resistance ( by HOMA IR) in adult Indian obese patients.	3 months
• To study the effect of weight loss on insulin resistance and body fat distribution in adult Indian obese patients	3 months

Trial Locations

Locations (1)

AIIMS; 🇮🇳 South, DELHI, India

AIIMS

🇮🇳South, DELHI, India

Dr Kumar Madhavan

Principal investigator

9555980494

madhavanranjit@gmail.com