Comparison of Inflammatory Parameters in Operated Ruptured and Non-ruptured Endometriomas
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 181
- 试验地点
- 1
- 主要终点
- Pre-interventional Comparison of inflammatory parameters
研究概览
简要总结
Ruptured endometrioma cases were compared with unruptured endometrioma cases.
详细描述
This study aims to compare the findings in patients who had surgery for ruptured endometrioma with the patients who had an unruptured endometrioma.
This study was conducted at Republic of Turkey Ministry of Health, Health Science University Etlik Zübeyde Hanım Gynecology Training and Research Hospital Infertility Clinic and all patients who were operated for endometrioma and had a histopathology report confirming the presence of endometrioma between January 2014 and December 2020 were included.
In this study, demographic characteristics, intraoperative findings, laboratory values and follow-up recommendations of two groups compared. The patients' age, presence of sexual activity and/or infertility, gravidity, parity, abortion, history of ectopic pregnancy, accompanying systemic disease, previous operations, drug use, and symptoms were recorded. Preoperative and postoperative complete blood count, Cancer antigen 125 (CA 125), Cancer antigen 19-9 (CA19-9), Cancer antigen 15-3 (CA 15-3), Carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), anti mullerian hormone (AMH), fibrinogen, C-reactive protein (CRP) values of the patients were obtained. Patient files, operation notes and laboratory values of the electronic recording system database and the two groups were compared.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 16 Years 至 48 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •All patients who were operated on in Republic of Turkey Ministry of Health, Health Science University Etlik Zübeyde Hanım Gynecology Training and Research Hospital Infertility Clinic, whose histopathological diagnosis was confirmed as endometrioma, and who did not meet the exclusion criteria, were included in the study.
排除标准
- •Patients who were operated with a prediagnosis of endometrioma and whose pathological diagnosis was different
- •Patients with smoking, alcohol, substance abuse
- •Patients receiving pelvic radiotherapy/chemotherapy
- •Patients with suspected or confirmed malignancies
结局指标
主要结局
Pre-interventional Comparison of inflammatory parameters
时间窗: Blood samples were taken from the patients before the surgery
Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), Monocyte/Lymphocyte ratio (MLR) were compared between two groups in the preoperative period
Comparison of inflammatory parameters after surgery
时间窗: Blood samples were taken from the patients in the first postoperative day.
Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), Monocyte/Lymphocyte ratio (MLR) were compared between two groups in the postoperative period
Pre-interventional Comparison of tumor markers
时间窗: Blood samples were taken from the patients before the surgery
Cancer antigens; CA125, CA19-9 and CA 15-3 were compared between two groups in the preoperative period
Comparison of tumor markers after surgery
时间窗: Blood samples were taken from the patients after the surgery up to 24 weeks
Cancer antigens; CA125, CA19-9 and CA 15-3 were compared between two groups in the postoperative period
次要结局
- Infertility(Before surgery)
- Sexual activity(Before surgery)
研究者
MD. Ayşe Gülen Erturun
Principal Investigator
EZH EAH