Het gebruik van indocyanine groen voor de detectie van de schildwachtklier bij mannen met prostaatkanker met een hoog risico op klier metastasen. Wetenschappelijk onderzoek naar het verbeteren van de schildwachtklierprocedure voor prostaatkanker met behulp van fluorescentie
Recruiting
- Conditions
- prostate cancer, sentinel node, lymph node, sentinel lymph nodeprostaat kanker, schildwachtklier, lymfeklier
- Registration Number
- NL-OMON20647
- Lead Sponsor
- The Netherlands Cancer Institute - Antoni van Leeuwenhoek HospitalPlesmanlaan 1211066CX AmsterdamThe Netherlands
- Brief Summary
van der Poel et al., Eur Urol 2011. - Buckle et al., JNM 2012.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 112
Inclusion Criteria
patients >18 years of age
- patients with histologically proven prostate cancer
- patients with an increased risk of nodal metastasis according to the MSKCC nomogram (>10%)
- scheduled for surgical (laparoscopic) prostatectomy including nodal dissection
Exclusion Criteria
- patients with a history of iodine allergy
- patients with a hyperthyroid or thyroidal adenoma
- patients with kidney insufficiency
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Further validation of the sentinel node procedure for prostate cancer via an ultrasound-guided transrectal ICG-99mTc-nanocolloid. <br>- Improve the intraoperative detection of the true tumor draining (tumor positive) sentinel nodes by improved injection techniques.
- Secondary Outcome Measures
Name Time Method Improve sentinel node dissection using combined radio- and fluorescence guidance after injection of the hybrid tracer and (in a subset of patients) a subsequent fluorescein injection prior to the start of the surgical procedure.