Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans
- Conditions
- Diet, HealthyCardiovascular DiseasesHypertension
- Interventions
- Other: Plant-Based DietOther: Typical American Diet
- Registration Number
- NCT05344287
- Lead Sponsor
- The University of Texas at Arlington
- Brief Summary
The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 19
- Self-identify as African American/Black
- Self-reported adherence to either a typical American diet (not following a specific diet pattern) or 100% plant-based (vegan) diet
- Age 18-40
- History of smoking within 2 years or being a current smoker
- Taking vasoactive medications
- Having overt cardiovascular, metabolic, or neurological disease
- Pregnant individuals
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Plant-Based Diet Plant-Based Diet African American individuals who self-report adhering to a plant-based diet prior to enrolling in the study. Typical American Diet Typical American Diet African American individuals who self-report adhering to a typical American diet prior to enrolling in the study.
- Primary Outcome Measures
Name Time Method Lipid profile (Total-C, LDL-C, VLDL-C, HDL-C, TG) Day 1 C-reactive protein Day 1 Post-occlusive brachial artery flow-mediated dilation (% change in brachial artery diameter from resting baseline) Day 1 Post-occlusive forearm reactive hyperemia (% change in brachial artery blood velocity from resting baseline) Day 1 Pulse wave velocity (carotid-to-femoral) Day 1 Central blood pressure (systolic, diastolic, mean) Day 1 Augmentation index (AIx@HR75) Day 1 Cerebral vascular reactivity (% change in cerebrovascular conductance index from resting baseline) Day 2 Local cutaneous thermal hyperemia (% change in cutaneous vascular conductance from resting baseline) Day 2 Peripheral blood pressure (systolic, diastolic, mean) Day 1
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UT Arlington - Science and Engineering Innovation and Research Building
🇺🇸Arlington, Texas, United States