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Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans

Completed
Conditions
Diet, Healthy
Cardiovascular Diseases
Hypertension
Interventions
Other: Plant-Based Diet
Other: Typical American Diet
Registration Number
NCT05344287
Lead Sponsor
The University of Texas at Arlington
Brief Summary

The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
19
Inclusion Criteria
  • Self-identify as African American/Black
  • Self-reported adherence to either a typical American diet (not following a specific diet pattern) or 100% plant-based (vegan) diet
  • Age 18-40
Exclusion Criteria
  • History of smoking within 2 years or being a current smoker
  • Taking vasoactive medications
  • Having overt cardiovascular, metabolic, or neurological disease
  • Pregnant individuals

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Plant-Based DietPlant-Based DietAfrican American individuals who self-report adhering to a plant-based diet prior to enrolling in the study.
Typical American DietTypical American DietAfrican American individuals who self-report adhering to a typical American diet prior to enrolling in the study.
Primary Outcome Measures
NameTimeMethod
Lipid profile (Total-C, LDL-C, VLDL-C, HDL-C, TG)Day 1
C-reactive proteinDay 1
Post-occlusive brachial artery flow-mediated dilation (% change in brachial artery diameter from resting baseline)Day 1
Post-occlusive forearm reactive hyperemia (% change in brachial artery blood velocity from resting baseline)Day 1
Pulse wave velocity (carotid-to-femoral)Day 1
Central blood pressure (systolic, diastolic, mean)Day 1
Augmentation index (AIx@HR75)Day 1
Cerebral vascular reactivity (% change in cerebrovascular conductance index from resting baseline)Day 2
Local cutaneous thermal hyperemia (% change in cutaneous vascular conductance from resting baseline)Day 2
Peripheral blood pressure (systolic, diastolic, mean)Day 1
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

UT Arlington - Science and Engineering Innovation and Research Building

🇺🇸

Arlington, Texas, United States

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