Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans

Completed

• Conditions: Diet, Healthy; Cardiovascular Diseases; Hypertension
• Interventions: Other: Plant-Based Diet; Other: Typical American Diet

• Registration Number: NCT05344287
• Lead Sponsor: The University of Texas at Arlington

Brief Summary

The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-12
• Primary Completion: 2020-01-13
• Study Completion: 2020-01-13
• Status Verified: 2022-04
• Study First Submitted: 2022-04-12
• Study First Submitted QC: 2022-04-19
• Study First Posted: 2022-04-25
• Last Update Submitted: 2022-04-28
• Last Update Posted: 2022-05-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• Self-identify as African American/Black
• Self-reported adherence to either a typical American diet (not following a specific diet pattern) or 100% plant-based (vegan) diet
• Age 18-40

Exclusion Criteria

• History of smoking within 2 years or being a current smoker
• Taking vasoactive medications
• Having overt cardiovascular, metabolic, or neurological disease
• Pregnant individuals

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Plant-Based Diet	Plant-Based Diet	African American individuals who self-report adhering to a plant-based diet prior to enrolling in the study.
Typical American Diet	Typical American Diet	African American individuals who self-report adhering to a typical American diet prior to enrolling in the study.

Primary Outcome Measures

Name	Time	Method
Lipid profile (Total-C, LDL-C, VLDL-C, HDL-C, TG)	Day 1
C-reactive protein	Day 1
Post-occlusive brachial artery flow-mediated dilation (% change in brachial artery diameter from resting baseline)	Day 1
Post-occlusive forearm reactive hyperemia (% change in brachial artery blood velocity from resting baseline)	Day 1
Pulse wave velocity (carotid-to-femoral)	Day 1
Central blood pressure (systolic, diastolic, mean)	Day 1
Augmentation index (AIx@HR75)	Day 1
Cerebral vascular reactivity (% change in cerebrovascular conductance index from resting baseline)	Day 2
Local cutaneous thermal hyperemia (% change in cutaneous vascular conductance from resting baseline)	Day 2
Peripheral blood pressure (systolic, diastolic, mean)	Day 1

Trial Locations

Locations (1)

UT Arlington - Science and Engineering Innovation and Research Building; 🇺🇸 Arlington, Texas, United States