MyKids: Molecular Identification and Characterization of non-Rhabdomyosarcoma Soft Tissue Sarcoma in Kids, Adolescents and Young Adults: an EpSSG NRSTS study
- Conditions
- NRSTSSoft-tissue sarcoma10072990
- Registration Number
- NL-OMON53798
- Lead Sponsor
- Prinses Máxima Centrum voor Kinderoncologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
-Patients within 2 months after new diagnosis of NRSTS
-Age 0-25 years
-Written informed consent by patients and/or patients/legal representatives and
patients according to local law and legislation
-Minimal requirements for study participation: diagnostic FFPE material and
peripheral blood for germline analysis for WP2
Exclusion Criteria
-Relapsed NRSTS, not included at diagnosis
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>WP2:<br /><br>- Determine molecular diagnosis on FFPE with mRNAseq.<br /><br>- Comparative Genome Hybridization (aCGH) for determination of genomic index<br /><br>(GI).<br /><br>- Fédération Nationale des Centers de Lutte Contre le Cancer (FNCLCC) grading.<br /><br>- CINSARC signature: complexity Index in Sarcoma; an expression profile<br /><br>signature to predict tumor aggressiveness and metastatic outcome in<br /><br>non-translocation-associated sarcomas, based on a 67-gene signature related to<br /><br>chromosome integrity and genome complexity. </p><br>
- Secondary Outcome Measures
Name Time Method