Molecular studies in a multigenerational family with gastro-esophageal reflux disease (GERD)
- Conditions
- GERDheartburn1001801810017977
- Registration Number
- NL-OMON35981
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 23
- Affected family members and all adult unaffected family members will be asked to participate. Family members are considered to be affected either if a diagnosis of GERD has been made by a physician (usually a [pediatric] gastroenterologist), if additional investigations such as pH/impedance measurements or gastroesophageal endoscopies show evidence for GERD, or if anti-reflux surgery has been performed in the past. GERD is considered as a dichotomous trait in this study.
- Informed consent is needed to be included. Informed consent will be asked for by the parents when children are under the age of 12 years. At present there is only a single affected child (8 yrs) in this family.
Insufficient understanding of the purpose and risks of the study.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome is linkage to one or more chromosome regions and<br /><br>idenfication of associated gene(s) in the GERD family. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary outcome will consist of a thorough description of the clinical<br /><br>characteristics, the phenotype, of patients with GERD in this family. </p><br>