Searching for GENes in families with frontotemporal dementia, dementia with Lewy bodies and early onset alzheimer DEMentia
- Conditions
- Alzheimer diseasefrontotemporal dementia1008362410029305
- Registration Number
- NL-OMON38398
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
1.Families with (probable) autosomal dominant inheritance of frontotemporal dementia, dementia with Lewy bodies or early onset Alzheimer dementia.
- Families fitting autosomal dominant inheritance:
o Frontotemporal dementia or dementia with Lewy bodies in at least three persons in two consecutive generations, or
o Alzheimer dementia in at least three persons in two consecutive generations all with an onset below the age of 65 years.
- Families suggestive of autosomal dominant inheritance:
o Frontotemporal dementia or dementia with Lewy bodies in at least two persons, or
o Alzheimer dementia in at least three persons, 1st or 2nd degree related to each other, of whom at least one has an onset below the age of 65 years, or
o Alzheimer dementia in at least two persons, 1st or 2nd degree related to each other, with both an onset below the age of 65 years.;2. A sufficient understanding of the Dutch language and cognitive abilities to understand questions and procedures of participants or their (legal) representatives
* Families in which a causal mutation has been identified
* Families that are known to be unwilling to participate in research
* Families in which no DNA of any affected person is or will be available
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>identifying genes causing frontotemporal dementia, dementia with Lewy bodies<br /><br>and early onset Alzheimer dementia</p><br>
- Secondary Outcome Measures
Name Time Method <p>n/a</p><br>