Identifying genetic determinants of Familial Barrett*s esophagus and adenocarcinoma of the gastro-esophageal junctio

Withdrawn

Conditions: adenocarcinoma of the gastro-esophageal junction
Barrett's esophagus
10017934
10017991

Registration Number: NL-OMON41007

Lead Sponsor: Maag-, Darm- en Leverziekten

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

As described earlier, we identified in a collaborative effort (with the Departments of Surgery and Medical Genetics) 20 index patients from families that fulfill the criteria for familial BE or adenocarcinoma of the GEJ. Apart from the retrospectively identified index patient, new index patients identified during this study by the department of Medical Genetics will also be eligible for this study,;The criteria for familial BE or adenocarcinoma of the GEJ:
A. Two or more first- or second degree relatives with BE or adenocarcinoma of the GEJ, with at least one diagnosed before the age of 50
B. Three or more first- or second degree relatives with BE or adenocarcinoma of the GEJ, irrespective of age
C. One patient with BE or adenocarcinoma of the GEJ < 40 yrs;For this study, individuals that meet the following inclusion criteria are eligible:
All first degree relatives (i.e. sons, daughters, sisters, brothers and father and mother of the index patient) of the index patient

Exclusion Criteria

A potential individual who meets any of the following criteria will be excluded from participation in this study:
1) Individuals < 25 and > 75 years old
2) Unable to fill out questionnaire

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Determine the prevalence of BE among first degree relatives of index patients<br /><br>of families that fulfil criteria for familial BE/adenocarcinoma of the GEJ<br /><br><br /><br>Determine the number and type of (pre) malignant lesions in first degree<br /><br>relatives of index patients of families that fulfil criteria for familial<br /><br>BE/adenocarcinoma of the GEJ</p><br>

Secondary Outcome Measures