The influence of a genetic difference in the bradykinin B1 receptor gene on the inflammatory response of bradykinin B1 receptor stimulation in human mononuclear cells.

• Conditions: coronary heart disease; Heart and Vascular disease; 10011082

• Registration Number: NL-OMON37396
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 44

Inclusion Criteria

Healthy persons within the age group of 18-60 years.

Exclusion Criteria

Use of ACE inhibitors, AT1 receptor blocker or renin inhibitor.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in gene-expression of inflammatory genes in response to bradykinin B1<br /><br>receptor stimulation in human mononuclear cells in the presence or absence of<br /><br>the rs12050217 minor allele. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are to test if the inflammatory response is<br /><br>influenced by stimulation or inhibition of other components of the RAS or kinin<br /><br>system and evaluation of the plasma for the presence of inflammatory cytokines<br /><br>and RAS hormones. In addition, genetic analysis of other SNP*s in the RAS and<br /><br>kinin system in relation to the inflammatory response is also a secondary<br /><br>measurement. </p><br>