Whole genome sequencing of children born after fertilization with ICSI using testicular sperm

Completed

• Conditions: observationele studie van nakomelingen van onvruchtbare mannen; genetic anomalies; 10027664

• Registration Number: NL-OMON37802
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-06-29
• Results First Posted: 2016-06-29
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Ten trios (10 children and parents) will be tested. The only inclusion criteria for this study is that children are born after fertilization with testicular sperm and ICSI from males (father) with a non obstructive azoospermia (poor spermatogenesis).

Exclusion Criteria

All other children and parents that do not meet the inclusion criteria. Fathers with a known genetic anomaly will be excluded from the study. Language barrier for understanding the reason for this study.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The number and type of de novo mutations found in the study group (TESE-ICSI<br /><br>children). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>