Added Value of Mechanically-assisted Ventilation in the Treatment of Moving Tumours (Thoracic/Upper Abdomen) With Photon and Proton Therapies.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Thoracic Neoplasm
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Enrollment
- 23
- Locations
- 1
- Primary Endpoint
- Measure in millimeters of the internal motion during non-invasive mechanically assisted ventilation, based on MRI images
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Mechanical ventilation can be used to impose a completely regular pattern of breathing frequency and inflation volume on the patient for as long as required. This would considerably improve the reproducibility of the internal motion parameters, and thus facilitate the implementation of respiratory-synchronized techniques such as gating, tracking and four-digital optimization.
Detailed Description
This will be a three-phase analysis : First, different ventilation modes will be tested and compared on healthy volunteers. This phase will be analysed with a ventilator and with dynamic MRI in order to measure the movement of anatomical structures in each ventilation mode (intra-fraction analysis). Further, we will repeat these exams in order to compare them with the first ones, in order to analyse the reproducibility and baseline shifts (inter-fraction analysis). Here are the different ventilation modes * spontaneous breathing * physiologic ventilation mode : * shallow ventilation mode * slow ventilation mode * Jet Ventilation mode Second phase will be done with patients that are intended to have a radiation treatment for thoracic or upper abdominal tumors. All the previous ventilation modes will be analysed during repeated MRI, again in order to perform intra- and inter-fraction analysis of the tumor motion. Third phase also concerned patients intended to have a radiation treatment. It will be an in-silico-planning analysis in order to quantify dosimetric outcomes of these ventilation modes.
Investigators
Eligibility Criteria
Inclusion Criteria
- •No comorbidity for healthy volunteers
- •Cancer patients with either lung or upper abdomen (liver/pancreas) tumours treated with radiation therapy.
Exclusion Criteria
- •severe lung disease or emphysema
- •previous history of pneumothorax
- •claustrophobia
Outcomes
Primary Outcomes
Measure in millimeters of the internal motion during non-invasive mechanically assisted ventilation, based on MRI images
Time Frame: within 12 months
This analysis will be based on dynamic MRI analysis made with healthy volunteers and also patients on non-invasive mechanically assisted ventilation. A well defined anatomical structure will be selected for the healthy volunteers while the tumor will be tracked in patients.
Secondary Outcomes
- Dosimetric comparison(within 12 months)
- Tolerance assessment(within 12 months)
- Internal motion reproducibility with non-invasive mechanically assisted ventilation.(Within 12 months)