Criteria Analysis for Ventilatory Support Adjustment of Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 4
- 主要终点
- Measuring muscular force
研究概览
简要总结
The indications for mechanical ventilation (MV) include excessive work of breathing, with or without evidence of respiratory muscle fatigue. The setting of the MV is still a challenge because it is based on criteria understudied, often subjective and observer-dependent. Despite several studies, to our knowledge has never been done before is the precise definition of the optimal range of ventilatory support. Novel and recognizable diagnostic techniques will be applied. No single parameter of the breathing pattern has good accuracy for the adjustment of ventilatory support. Non-invasive measures such as P0.1 and rate of muscle relaxation may have good accuracy for the adjustment of ventilatory support.
详细描述
Use of excessive pressure support
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients under invasive mechanical ventilation for 48h
- •patients without the objective of complete rest of the respiratory muscles. This decision will be on the discretion of the attending physician,
- •spontaneous breathing,
- •clinically stability.
排除标准
- •Previous disease of the central nervous system that can lead to respiratory changes.
- •Previous disease of the peripheral nervous system that can lead to respiratory changes
- •Previous muscular disease.
结局指标
主要结局
Measuring muscular force
时间窗: From the baseline ventilation to the minimum level of pressure support. Around 3 hours
Muscular force measured by inspiratory force in centimeters of water (cmH2O)
次要结局
- Measuring inspiratory drive(From the baseline ventilation to the minimum level of pressure support. Around 3 hours)
- Measuring endurance(From the baseline ventilation to the minimum level of pressure support. Around 3 hours)