Comparison of the efficacy of topical betamethasone, systemic colchicine and a combination of both therapies on the severity of recurrent aphthous stomatitis: a randomised clinical trial

Guys and St Thomas NHS Trust0 个研究点目标入组 100 人开始时间: 2018年4月15日最近更新: 2023年10月16日

适应症

试验速览

2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37789351/ (added 04/10/2023)

•1. Diagnosed with RAS (defined as recurrent oral ulcers of unknown aetiology characterised by the spontaneous emergence of more than two bouts of oral ulcers per year, not associated with ulcers elsewhere in the body or with an underlying systemic abnormality).
•2. Aged between 18-65 years.
•3. Willing and able to give informed consent to participate in the study.
•4. Not involved in other studies that would compromise their safety or undermine the scientific basis of the study.

•1. Unable to give informed consent.
•2. Unwilling or unable to comply with the study protocol.
•3. Pregnant or breast feeding.
•4. Atopic or have severe or relevant history of allergy, hypersensitivity or side effects to any of the study medications.
•5. Diagnosed with systemic diseases thought to overlap with RAS i.e. Behcet’s disease, HIV, haematological deficiencies, gastrointestinal or dermatological disorders.
•6. Patients with a current or past history of cardiac, renal,or hepatic disease.
•7. Patients who were on any type of local or systemic Steroids or on Colchicine currently or in the previous three months.
•8. Patients who are debilitated in any way.

发起方

Guys and St Thomas NHS Trust