Magnesium Versus High Dose Fentanyl in Endotracheal Intubation
Not Applicable
Completed
- Conditions
- Stress Response
- Interventions
- Drug: Magnesium sulfate- Fentanyl
- Registration Number
- NCT04544163
- Lead Sponsor
- National Cancer Institute, Egypt
- Brief Summary
this study is designed to assess the efficacy of MgSO4 versus high dose fentanyl compared to conventional anesthesia in attenuating stress response to intubation
- Detailed Description
to assess the effect of MgSO4 combined with fentanyl compared to high dose fentanyl in attenuating stress response in cancer patients undergoing surgeries under general anesthesia requiring endotracheal intubation
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
- Cancer patients undergoing surgery under general anesthesia requiring endotracheal intubation
- ASA I II
- 18 to 60
Exclusion Criteria
- allergy to any of the used drugs
- renal or hepatic impairment
- hypertensive patients, patients with cardiovascular or cerebrovascular diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Magnesium sulphate- Fentanyl Fentanyl 2Mcg/kg 30 mg per kg MgSo4 infusion in 100 ml saline over 10 minutes Fentanyl Fentanyl 2Mcg/kg 2 mic per kg fentanyl i.v Magnesium sulphate- Fentanyl Magnesium sulfate- Fentanyl 30 mg per kg MgSo4 infusion in 100 ml saline over 10 minutes Fentanyl 4 mic Fentanyl 4Mcg/kg 4 mic per kg fentanyl i.v Lidocaine- Fentanyl Fentanyl 2Mcg/kg Lidocaine 1.5 mg/kg Lidocaine- Fentanyl Lidocaine 1.5 mg/kg Lidocaine 1.5 mg/kg
- Primary Outcome Measures
Name Time Method heart rate values 5 minutes changes in heart rate values after intubation
- Secondary Outcome Measures
Name Time Method coughing during intubation lntubation time coughing during intubation
blood pressure 5 minutes mean arterial blood pressure values
Trial Locations
- Locations (1)
Walaa Y Elsabeeny
🇪🇬Cairo, Egypt