The influence of sarcopenia and cancer cachexia on recovery of gastric and colonic surgery

Recruiting

Conditions: colorectal cancer
gastric cancer
sarcopenia
10017990
10017998

Registration Number: NL-OMON37020

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 90

Inclusion Criteria

Patients undergoing gastric or colonic resection of a primary tumor who are older than 80 years or younger than 60 years of age. Surgery types: gastric: BII subtotal gastrectomy, total gastrectomy with Roux and Y reconstruction. Colon: right hemicolectomy, left hemicolectomy, sigmoid resection. Both open resections and laparoscopic resection will be included.
Patients undergoing abdominal wall incisional hernia repair who are older than 80 years or younger than 60 years of age.

Exclusion Criteria

Metastasized tumors (TNM stage M1 or higher). To avoid variation of tumorload within patient groups, patients with metastases beyond lymph nodes will be excluded.
Acutely ill patients will be excluded as this influences inflammatory markers. Acutely ill is defined as: pneumonia, urinary tract infection, (intra-abdominal) abscess, etc.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>On frozen sections of muscle biopsies, the next parameters will be<br /><br>investigated: fiber typing, quantity of fibers, mean fiber cross sectional<br /><br>area, the number of satellite cells per fiber. Moreover, apoptosis is studied,<br /><br>which is an important process prior to muscle wasting in cancer patients.<br /><br>The primary study outcome is the difference in muscle composition between<br /><br>elderly (>80) and younger (<60) cancer patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Fat tissue: inflammation.<br /><br>Colonic tissue: collagen composition, proliferation, inflammation, apoptosis,<br /><br>goblet cells, mucins and prostaglandins. These factors have an important<br /><br>function in intestinal healing.<br /><br>Gastric tissue: collagen composition, proliferation, inflammation, apoptosis<br /><br>and prostaglandins. These factors have an important function in gastric healing.<br /><br>Plasma: inflammation, markers of intestinal damage.</p><br>