Non-invasive Measurement of Neonatal Central and Peripheral Hemodynamics, as Valuable Diagnostic and Treatment Efficiency Criterium of Neonatal Sepsis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pre-Term
- Sponsor
- Vilnius University
- Enrollment
- 163
- Locations
- 1
- Primary Endpoint
- Weight measurement
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Non-invasively neonatal cardiac output can be measured by multiple methods, but the gold standard still remains conventional echocardiography. It is accurate, but needs a long training for new users to assess cardiac function. Continuous-wave Doppler ultrasound monitor USCOM is a relatively new monitor which can perform faster and less complex cardiac function measurement, also it is easier for the operator to get trained. The aim of the study is to assess the level of agreement between cardiac output measured with conventional echocardiography and with USCOM, to present normal ranges for neonates of different gestational age and to look for early signs of hemodynamic changes during sepsis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •newborns of any gestational age
- •parental consent acquired
Exclusion Criteria
- •congenital malformations
- •hemodynamic instability in control group
- •any respiratory support in control group
- •infection in control group
Outcomes
Primary Outcomes
Weight measurement
Time Frame: 1 minute
weight in grams
Height measurement
Time Frame: 1 minute
length in centimeters
Echocardioscopy to measure velocity time integral
Time Frame: 3 minutes
Echocardiography to measure velocity time integral at the aortic valve in centimeters. After that the software of the device calculates cardiac output.
Near- Infrared Spectroscopy for regional blood flow
Time Frame: 15-20 minutes
One sensor on the forehead, another- on the back to check for regional blood flow in the brain and kidney with Near- Infrared Spectroscopy
USCOM examination
Time Frame: 3-5 minutes
USCOM 1A uses continuous wave Doppler for flow curves, which are obtained at the suprasternal notch for an optimal flow signal at the aortic valve. The software of the device calculates cardiac output then
Chest and head circumference
Time Frame: 1 minute
Chest and head circumference in centimeters
Blood pressure measurement
Time Frame: 1 minute
non- invasive arterial blood pressure measurement in mmHg
Pulse rate measurement
Time Frame: 1 minute
pulse rate in beats per minute
Echocardioscopy for left ventricular outflow tract diameter
Time Frame: 2-3 minutes
Echocardiography for left ventricular outflow tract diameter in centimeters