Impact of Aerobic Versus Resistive Training on Functional Capacity in Acute Myeloid Leukemia Survivors; a Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Six minutes walking Distance
研究概览
简要总结
Sixty patients with AML from both sexes aged from 35-45 years were selected from hematology department in Nasser Institute Hospital where the study was conducted. Patients were randomly assigned into two groups equal in number. Group (A) underwent aerobic exercises in the form of cycling with 50-60% of maximum heart rate. Group (B) underwent resistive training conducted in the form of a series of exercises using free weights, and dumbles. Sessions were conducted three times /week for eight weeks. Six minutes' walk test (6MWT), 10 repetitions maximum test (10 RM), ventilatory function test, fatigue and quality of life (QOL) scales were used to assess functional capacity in both groups.
详细描述
Aerobic Ex Group: Included 30 patients who underwent aerobic training with 50 %-60% of maximum heart rate in the form of cycling by Bicycle ergometer for eight weeks, three sessions/week.
Resistive Ex Group: Included 30 patients who underwent a resistive training which were conducted in the form of a series of exercises using free weights, and dumbles to increase the strength of arms, pectoral muscles, abdominal, back muscles and gluteal region. Patients carried out three sets of 20-30 dynamic repetitions or static isometric exercises for 40-60 seconds for each muscle group and rested 1-2 min between series. Sessions were conducted three sessions/week for eight weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute myeloid leukemia survivors from both sexes
- •Their age ranged from 35-45 years.
- •Patients were in remission stage contains less than 5% blast cells in their bone marrow, absolute neutrophil count (>1000/microL), platelet count(>100,000/microL),and independence from red cell transfusion.
排除标准
- •Extramedullary leukemia
- •musculoskeletal deformities
- •severe anemia (hemoglobin less than 8g/dl).
- •Autoimmune thrombocytopenia (platelets less than 10000UL or leucocytes count more than 3000UL).
结局指标
主要结局
Six minutes walking Distance
时间窗: It is performed before and after the study(8 weeks interval) for both groups
which used to measure the distance the patient was able to walk over a total of six minutes According to American thorax society guidelines; patients were instructed to walk as fast as long as possible , in a 30 meters obstacle free corridor limited by turnaround cones and distance was calculated
10 repetition maximum test
时间窗: It is performed before and after the study(8 weeks interval) for both groups
which the greatest amount of weight a person can lift number of times. The amount of weight that can be lifted exactly 10 times is 10 RM
Vital capacity
时间窗: It is performed before and after the study(8 weeks interval) for both groups
was measured by using electronic spirometry used to conduct ventilatory function testing
次要结局
- Maximum oxygen consumption(It is performed before and after the study(8 weeks interval) for both groups)
- Fatigue assessment scale (FAS)(It is performed before and after the study(8 weeks interval) for both groups)
- Quality of life questionnaire (QOL)(It is performed before and after the study(8 weeks interval) for both groups)
研究者
Heba Ahmed Ali Abdeen
Assistant Professor
Cairo University