Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial
- Registration Number
- NCT00745849
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Brief Summary
The purpose of this study was to see if high dose esomeprazole (40mg bid) was effective in treating non-allergic rhinitis
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 43
Inclusion Criteria
- age between 18-80, symptoms of perennial rhinitis, negative epicutaneous skin testing to a panel of common aeroallergens, and ability to speak English
Exclusion Criteria
- pregnancy or breast-feeding, evidence of positive skin tests to a common aeroallergen, treatment with a proton pump inhibitor within the month prior to enrollment, treatment with any other anti-reflux therapy within the last month on a daily basis or within the last two weeks on an as needed basis, and other gastrointestinal disorders leading to reflux symptoms
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 2 placebo - 1 esomeprazole esomeprazole 40mg po bid
- Primary Outcome Measures
Name Time Method Total Nasal Symptom Scores Last two weeks of each treatment arm (1=none, 7=unbearably severe) difference in nasal symptom scores for the average of the last two weeks of each treatment arm
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Clinical Trials Office, Aston Building, UT Southwestern
🇺🇸Dallas, Texas, United States