HIGH Altitude CArdiovascular REsearch Latin America Population Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 937
- 试验地点
- 1
- 主要终点
- Difference in 24 h ambulatory systolic BP between lowlanders and highlanders.
研究概览
简要总结
High blood pressure (BP) is one of the principal cardiovascular risk factors. While BP levels and hypertension prevalence are well characterized in many populations, information on BP and on cardiovascular risk profile in high altitude inhabitants is limited and frequently contradictory, especially in the large highland populations of South America. The information on the effects of permanent high altitude exposure on cardiovascular variables including BP may be relevant in the light of the known BP-increasing effect of acute exposure to high altitude hypoxia. This information may have practical implications for millions of people living at elevated altitudes in Asia, South America and Africa.
The inconclusive epidemiological evidence on BP and cardiovascular risk in high altitude dwellers may be the result of several factors, among them: 1) confounding by genetic and socio-economic factors; 2) imperfect methods of BP evaluation, in particular lack of data on ambulatory and home BP (both methods considered superior to conventional clinic BP in the assessment of exposure to high BP).
On this background, the general aim of the study is to compare blood pressure levels and cardiovascular risk profile among population-based samples of subjects residing in Peruvian communities living at different altitudes.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult (>18 years) male and female subjects;
- •Highlanders: permanence at high (>2500 m) altitude;
- •Lowlanders: permanence at low (<1500 m) altitude;
- •Written informed consent to participate in the study
排除标准
- •Lowlanders who over 3 months preceding inclusion in the study spent considerable (> 7 consecutive days) amount of time at altitudes above 1500 m;
- •Highlanders who over 3 months preceding inclusion in the study spent considerable (>7 consecutive days) amount of time at altitudes below 2500 m;
- •Subjects cognitively incapable of providing informed consent or responding to a questionnaire
- •Physical disability that would prevent study assessments from being performed
- •Active pulmonary tuberculosis
- •Pregnancy
结局指标
主要结局
Difference in 24 h ambulatory systolic BP between lowlanders and highlanders.
时间窗: baseline
次要结局
- Difference in home systolic and diastolic BP between lowlanders and highlanders(baseline)
- Differences in 24 h DBP, daytime and night-time systolic and diastolic BP between lowlanders and highlanders(baseline)
- Difference in conventional systolic and diastolic BP between lowlanders and highlanders(baseline)
- Difference in sleep duration between lowlanders and highlanders(baseline)
- Difference in a number of BP variables between highlanders living at three high altitude levels(baseline)
- Difference in sleep quality between lowlanders and highlanders(baseline)
- Difference in estimated cardiovascular risk(baseline)
- Difference between lowlanders and highlanders in hypertension prevalence(baseline)