The effect of dietary nitrate supplementation on dynamic cerebral autoregulation in ischaemic stroke

Not Applicable

Completed

Conditions: Stroke
Circulatory System

Registration Number: ISRCTN84197855

Lead Sponsor: South Devon Healthcare NHS Foundation Trust (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 16

Inclusion Criteria

1. Subjects must have a confirmed onset of acute ischaemic stroke within the last 14 days
2. Age 18-90
3. Able to lie supine and still for 30 minutes
4. Able to take liquid orally
5. Able to give full informed consent
6. Adequate temporal acoustic window as assessed with transcranial doppler ultrasound

Exclusion Criteria

1. Stroke onset within 24 hours
2. Haemorrhagic stroke
3. Pregnant women
4. Dysphagia precluding oral intake of liquid
5. Inadequate temporal acoustic window for transcranial ultrasound
6. Exclude vasoactive drugs including calcium channel blockers
7. Regularly taking organic nitrates, nicorandil, glitazones, phosphodiesterase inhibitors
8. Pre-existing dementia
9. Significant carotid stenosis >70% on carotid doppler
10. Severe peripheral vascular disease

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The Correlation Coefficient (nMx), a marker of dynamic cerebral autoregulation, at 2 hours following ingestion of the investigational product

Secondary Outcome Measures

Name	Time	Method
1. Plasma nitrate level<br>2. Mean arterial blood pressure<br>3. Standard cerebral haemodynamics<br>4. National Institutes of Health Stroke Scale (NIHSS)<br>5. Modified Rankin Score (mRS)<br><br>Measured at 2 hours following ingestion of the investigational product.