Bio-psycho-social Pathways Underlying the Effects of Qigong Among Comorbid Depressed Elderly With Chronic Conditions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Disease
- Sponsor
- The Hong Kong Polytechnic University
- Enrollment
- 35
- Locations
- 1
- Primary Endpoint
- Patient Health Questionnaire (PHQ)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Depression and chronic medical conditions are common in older adults. Qigong is increasingly documented to have anti-depressive effects for older adults. Nevertheless, the scientific concepts behind qigong remain a mystery. To fill the knowledge gap, the neurobiological mechanism of the effects of qigong was explored. In addition, the benefits of qigong on subjective well-being, functional independence, sleep quality, mobility, and muscle strength were also tested. After random assignment, intervention group (n = 14) went through individual qigong exercise twice a week and for 12 weeks,whereas control group (n = 16) was involved in cognitive training activities with mobilization elements. The psychosocial, physical, and neurobiological outcomes of the two groups were compared.
Investigators
TSANG Hector Wing-Hong
Professor and Head of Department of Rehabilitation Sciences
The Hong Kong Polytechnic University
Eligibility Criteria
Inclusion Criteria
- •aged 60 or above
- •have been suffering from chronic medical conditions for more than one year
- •have depressive symptoms as indicated by Geriatric Depression Scale (GDS ≥ 6)
Exclusion Criteria
- •have practiced or received training of any form of mind-body exercises (including tai chi, yoga, and qigong) during the 6 months prior to intervention.
- •have changed medication or the dosage prior to or during intervention
- •have obvious cognitive and language impairment or score less than 20 in Mini-Mental State Examination (MMSE)
- •undergo electroconvulsive therapy, psychotherapy, or psychoeducation
- •cannot demonstrate satisfactory sitting balance
Outcomes
Primary Outcomes
Patient Health Questionnaire (PHQ)
Time Frame: the change from baseline to the completion of intervention (12 weeks later)
Patient Health Questionnaire (PHQ) is used to assess the experience of depressive symptoms. The frequency of each symptom was indicated based on a 4-point scale (0 = never; 3 = almost every day). A total score ranged from 0 to 27 can be derived, with higher score indicating severer depressive symptoms.
Secondary Outcomes
- Brain Deprived Neurotrophic Factor (BDNF) Level(baseline and 12 weeks after baseline)
- Depression Anxiety Stress Scale (DASS-21)(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Personal Well-Being Index (PWI)(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Functional Independence Measure (FIM)(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Timed up and Go Test (TUG)(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Handgrip Strength(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Salivary Cortisol Level(baseline and 12 weeks after baseline)
- Serotonin 5-HT Level(baseline and 12 weeks after baseline)
- Pittsburgh Sleep Quality Index (PSQI)(baseline, 12 weeks after baseline, and 16 weeks after baseline)