Boston Puerto Rican Health Study - Project 4
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Blood biomarkers
研究概览
简要总结
The study is a blinded cross over test of in-home air filtration. Participants will have a window unit air filter (HEPA) installed that will filter for 3 weeks and do sham filtration for another 3 weeks. During the time that the filter is installed in the home a machine that measures particulate air pollution of the type that the filter is designed to remove will be installed. A survey will be administered, blood samples taken and blood pressure measured immediately prior to starting the filter, at 3 weeks when the filtration is changed from sham to real filtration or visa versa and at the end of the second three week period. All participants will be recruited from the Boston Puerto Rican Health Study cohort.
详细描述
Project 4 Protocol:
I. Aims and Hypotheses
H1: That in-home active HEPA filtration will reduce ultrafine particle (UFP) levels >70% compared to sham filtration. Further, that HEPA filtration will reduce all size classes of ultrafine particles equally well.
H2: That markers of cardiovascular health, including C-reactive protein, fibrinogen, IL-6 and tumor necrosis factor alpha receptor, will be lower after living with active HEPA filtration compared to sham filtration.
H3: In-home HEPA filtration will be seen by policy-makers as an effective policy option for reducing UFP exposure in near-highway residences.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Participants were blinded as to filtration and no filtration. The lab was blinded as to which samples were from filtration or no filtration periods.
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant in the larger parent cohort of the BPRHS
排除标准
- •None since already enrolled in the cohort
结局指标
主要结局
Blood biomarkers
时间窗: 6 weeks
hsCRP, IL-6, TNFRII
次要结局
未报告次要终点