Effectiveness of Contingency Management in the Treatment of Crack Addiction in Brazil

Not Applicable

Completed

• Conditions: Substance Use Disorders; Addiction, Cocaine; Contingency Management

• Registration Number: NCT03345394
• Lead Sponsor: Federal University of São Paulo

Brief Summary

Crack addiction has become a severe public health problem in Brazil. Crack users present elevated prevalence rates of psychiatric comorbidities, sexual transmitted infections and unemployment with high probability of living or have lived in the streets, history of incarceration and engagement in illegal activities. For the last 20 years a treatment called Contingency Management (CM) have achieved the best results regarding reduction of substance use, promotion of abstinence, treatment attendance and retention in treatment. The first CM study conducted in Brazil advocates for the efficacy of CM on all of these outcomes, suggesting that CM can be effective in a Brazilian population of crack users.

Detailed Description

The objective of this study is to evaluate the effectiveness of Contingency Management (CM) for crack users living in the "Crackland" region. To achieve this goal, regular treatment staff from Unidade Recomeço Helvétia treatment service will be capacitated in CM to latter-on apply the CM intervention in their respective services. The design will be a single-blind randomized clinical trial composed of a sample of 100 subjects with current diagnose for crack/cocaine dependence. Participants allocated to the control condition will receive 12 weeks of the usual care treatment provided by these two treatment facilities. Participants allocated to the experimental condition will receive the exact same treatment as control participants associated with CM. CM procedure will occur 2 timer per week (every Monday and Thursday or Tuesday and Friday). Primary outcomes are: (1)retention in treatment; (2) reduction of crack use; (3) promotion of continuous crack cocaine abstinence. Secondary findings are reduction on psychiatric symptomatology. The investigator hypothesis is that participants in the CM condition will have a better treatment response in all studied outcomes.

Study Timeline

• Study First Submitted: 2017-11-14
• Study First Submitted QC: 2017-11-16
• Study First Posted: 2017-11-17
• Study Start: 2017-12-01
• Primary Completion: 2020-12-01
• Study Completion: 2020-12-01
• Results First Submitted: 2021-01-07
• Status Verified: 2021-03
• Results First Submitted QC: 2021-03-16
• Last Update Submitted: 2021-03-16
• Results First Posted: 2021-04-08
• Last Update Posted: 2021-04-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• DSM-V diagnose for crack cocaine use disorder

Exclusion Criteria

• being under 18 years old

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Pattern of Crack Cocaine Use	12 weeks	Percentage of negative crack cocaine urine samples submitted during the 12 weeks of treatment
Promotion of Continuous Crack Cocaine Abstinence	12 weeks	Longest duration of continuous abstinence achieved (in weeks)

Secondary Outcome Measures

Name	Time	Method
Treatment Retention	12 weeks	time elapsed between treatment entry and last time present in treatment (in weeks)

Trial Locations

Locations (1)

Unidade Recomeço Helvétia; 🇧🇷 São Paulo, Sao Paulo, Brazil