The Noninvasive Ventilation to COVID-19 Patients With Respiratory Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- the intubtion rate
研究概览
简要总结
Noninvasive ventilation(NIV) is an important treatment to the respiratory failure patients.The severe Corona Virus Disease-19(COVID-19) patients are incline to respiratory failure.The NIV may reduce the intubtion rate.This research was taken to investigate the factor to the success of the noninvasive ventilation to the COVID-19 patients with respiratory failure.
详细描述
Noninvasive ventilation(NIV) is an important treatment to the respiratory failure patients.The severe Corona Virus Disease-19(COVID-19) patients are incline to respiratory failure.The NIV may reduce the intubtion rate.This research was taken to investigate the factor to the success of the noninvasive ventilation to the COVID-19 patients with respiratory failure.We wish to raise the success rate to COVID-19 patients with respiratory failure.More critically ill COVID-19 patients could avoid the intubtion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Shortness of breath, RR>30 times per minute;
- •At room air, SpO2 lower than 93%;
- •The partial pressure of Arterial blood oxygen (PaO2)/the fraction of inspired oxygen (FiO2) ≤ 300mmHg;
- •CT（computed tomography） chest imaging shows that lung damage develops significantly within 24 to 48 hours.
排除标准
- •Severe cardiovascular disease,
- •respiratory arrest,
- •cardiovascular instability (hypotension, arrhythmias, myocardial infarction),
- •change in mental status or patients who were uncooperative, high risk of aspiration, viscous or copious
- •secretions,
- •recent facial or gastroesophageal surgery,
- •craniofacial trauma, 8)fixed nasopharyngeal abnormalities,
- •9）burns, 10) extreme obesity.
结局指标
主要结局
the intubtion rate
时间窗: 4 month
the intubtion rate of the COVID-19 patients
success rate
时间窗: 4 month
the sucess rate of the noninvasive ventilation
次要结局
- blood lymphocyte(4month)
- Procalcitonin(4 month)
- B-type natriuretic peptide(4 month)
- Oxygen Saturation(4 month)
研究者
Zhang Jianheng
The First Affiliated Hospital of Guangzhou Medical University
The First Affiliated Hospital of Guangzhou Medical University