The Noninvasive Ventilation to COVID-19 Patients With Respiratory Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Noninvavie Ventilation to Patients With COVID-19
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
- Enrollment
- 23
- Locations
- 1
- Primary Endpoint
- the intubtion rate
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Noninvasive ventilation(NIV) is an important treatment to the respiratory failure patients.The severe Corona Virus Disease-19(COVID-19) patients are incline to respiratory failure.The NIV may reduce the intubtion rate.This research was taken to investigate the factor to the success of the noninvasive ventilation to the COVID-19 patients with respiratory failure.
Detailed Description
Noninvasive ventilation(NIV) is an important treatment to the respiratory failure patients.The severe Corona Virus Disease-19(COVID-19) patients are incline to respiratory failure.The NIV may reduce the intubtion rate.This research was taken to investigate the factor to the success of the noninvasive ventilation to the COVID-19 patients with respiratory failure.We wish to raise the success rate to COVID-19 patients with respiratory failure.More critically ill COVID-19 patients could avoid the intubtion.
Investigators
Zhang Jianheng
The First Affiliated Hospital of Guangzhou Medical University
The First Affiliated Hospital of Guangzhou Medical University
Eligibility Criteria
Inclusion Criteria
- •Shortness of breath, RR\>30 times per minute;
- •At room air, SpO2 lower than 93%;
- •The partial pressure of Arterial blood oxygen (PaO2)/the fraction of inspired oxygen (FiO2) ≤ 300mmHg;
- •CT（computed tomography） chest imaging shows that lung damage develops significantly within 24 to 48 hours.
Exclusion Criteria
- •Severe cardiovascular disease,
- •respiratory arrest,
- •cardiovascular instability (hypotension, arrhythmias, myocardial infarction),
- •change in mental status or patients who were uncooperative, high risk of aspiration, viscous or copious
- •secretions,
- •recent facial or gastroesophageal surgery,
- •craniofacial trauma, 8)fixed nasopharyngeal abnormalities,
- •9）burns, 10) extreme obesity.
Outcomes
Primary Outcomes
the intubtion rate
Time Frame: 4 month
the intubtion rate of the COVID-19 patients
success rate
Time Frame: 4 month
the sucess rate of the noninvasive ventilation
Secondary Outcomes
- blood lymphocyte(4month)
- Procalcitonin(4 month)
- B-type natriuretic peptide(4 month)
- Oxygen Saturation(4 month)