Effects of chronic Tai Chi Chuan and aerobic exercise interventions on motor and neurocognitive performance in early-stage Parkinson’s disease
试验速览
- 阶段
- Unknown
- 状态
- 已完成
- 发起方
- 入组人数
- 43
研究概览
简要总结
The present study investigated and compared the effects of chronic Tai Chi Chuan and aerobic exercise interventions on neurocognitive performance in patients with early-stage PD. Twelve weeks of both types of exercise exhibited the potential to ameliorate the progressive decline in motor and neurocognitive functioning in such patients. The participants’ post-intervention UPDRS motor subscale scores were significantly lower than their pre-intervention scores in both exercise groups. In addition, both types of exercise resulted in a significantly increased P3 amplitude, although only the aerobic exercise also improved RT performance, as assessed using the WM task. However, neither intervention improved ARs or the N2 component measured during the cognitive task. In contrast, the control group exhibited a significant increase in UPDRS-III motor scores and a decrease in P3 amplitude over the 12-week period, suggesting that maintaining their sedentary lifestyle resulted in further motor and neurophysiological decline.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 50 Years 至 80 Years（—）
- 性别
- All
入选标准
- •The clinical inclusion criteria were as follows: (a) a confirmed diagnosis of PD by neurologists at the Neurology Department of one of the above hospitals, and a medically stable status; (b) a modified Hoehn & Yahr score between 1 and 2, indicating early-stage PD; (c) the absence of any major comorbidities, such as dementia or depression; (d) no brain abnormalities (e.g., stroke or malignant brain tumor) on structural MRI scans; (e) age between 50 and 80 years; (f) confirmed ability to complete exercise training, as determined using the Physical Activity Readiness Questionnaire (PAR-Q) and by their treating neurologist; and (g) willingness to be randomly assigned to one of the exercise intervention groups or the control group.
排除标准
- •Exclusion criteria were as follows: (a) a history of any neurological disease other than PD; (b) a diagnosis of dementia based on a MMSE or Montreal Cognitive Assessment (MoCA) score of < 24; (c) moderate or significant depression, as assessed based on a score of > 16 for the Beck Depression Inventory-II (BDI-II); (d) use of medication that interferes with cognition, alertness, or attention; or (e) previous or current participation in an exercise training program.