Evaluation of the Relationship Between Serum Myostatin and Irisin Levels and Bone Mineral Density and Muscle Strength in Postmenopausal Women
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- Relationship between serum myostatin and irisin levels and bone mineral density (T-score)
研究概览
简要总结
This study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Participants will be grouped according to bone mineral density as normal, osteopenic, or osteoporotic. Serum myostatin and irisin levels will be measured, and muscle strength will be assessed using handgrip strength and the five times sit-to-stand test. The associations between biochemical and functional parameters will be analyzed.
详细描述
This cross-sectional observational study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Postmenopausal women aged between 50 and 65 years who meet the inclusion criteria will be enrolled in the study. Bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA), and participants will be classified into three groups as normal, osteopenic, or osteoporotic according to T-scores.
Serum myostatin and irisin levels will be measured from venous blood samples collected after overnight fasting. Muscle strength will be evaluated using handgrip strength, and functional performance will be assessed with the five times sit-to-stand test. Demographic and clinical characteristics of the participants will also be recorded.
The relationships between serum myostatin and irisin levels and bone mineral density and muscle strength parameters will be analyzed using appropriate statistical methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Postmenopausal women aged between 50 and 65 years Availability of bone mineral density measurement by dual-energy X-ray absorptiometry (DEXA) Willingness to participate in the study
排除标准
- •Presence of malignancy Chronic kidney disease Chronic liver disease Neuromuscular disorders Recent major surgery or trauma Use of medications affecting bone or muscle metabolism
研究组 & 干预措施
Normal BMD
Postmenopausal women with normal bone mineral density based on dual-energy X-ray absorptiometry (DEXA) T-scores.
Osteopenia
Postmenopausal women with osteopenia defined by dual-energy X-ray absorptiometry (DEXA) T-scores.
Osteoporosis
Postmenopausal women with osteoporosis defined by dual-energy X-ray absorptiometry (DEXA) T-scores.
结局指标
主要结局
Relationship between serum myostatin and irisin levels and bone mineral density (T-score)
时间窗: Baseline
Serum myostatin and irisin levels will be measured from fasting venous blood samples, and bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA). The relationship between these parameters will be evaluated.
次要结局
- Relationship between serum myostatin and irisin levels and muscle strength(Baseline)
- Comparison of serum myostatin and irisin levels among bone mineral density groups(Baseline)
研究者
Zeynep Karakuzu Güngör
Specialist in Physical Medicine and Rehabilitation
Kanuni Sultan Suleyman Training and Research Hospital