Variations in composition of breast milk between different ethnic groups and the association with maternal nutrition and offspring health

Recruiting

Conditions: Breast milk composition
10036411

Registration Number: NL-OMON55936

Lead Sponsor: Wageningen Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 120

Inclusion Criteria

•Aged >18 years
•Having a pre-pregnancy BMI between 18.5 and 24.9 kg/m2
•>6 months pregnant at time of enrollment
•Able to provide a breast milk sample between the 4th and 8th week postpartum
•Planning to exclusively breastfeed until at least 3 months postpartum (this
will not include any formula given due to medical reasons within the first week
after delivery)
•Fulfilling the criteria of belonging to one of the three ethnicities of
interest (see 8.1.1)
•Written informed consent obtained

And her infant was:
• Delivered at full term, at 38 (starting at 37+1) -41 weeks
• Delivered apparently healthy (no diagnosed (chronic) illness)
• Delivered with a birthweight of at least 2,5 kg
• Delivered through vaginal delivery
• Not receiving antibiotics

Exclusion Criteria

Mothers cannot participate if they:
• Are expecting twins
• Cannot breastfeed their newborn
• Are currently deviating from their usual dietary pattern (following a diet
aimed to lose weight)
•Are experiencing symptoms of (chronic) conditions that might affect nutrient
absorption (e.g. Crohn's disease, Irritable Bowel Syndrome)
•Are diagnosed with a gastrointestinal disorder
• Are unable to read and understand the Dutch or English language

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Breast milk composition: analysis of lipids, proteins, enzymes, immuno<br /><br>proteins, hormones, amino-acids and carbohydrates<br /><br>- Maternal diet</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Infant gastrointestinal (GI) health<br /><br>- Infant development<br /><br>- Infant gut microbiota composition<br /><br>- Maternal nutritional status</p><br>