Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Generalized Aggressive Periodontitis
- Sponsor
- Ege University
- Enrollment
- 27
- Primary Endpoint
- Change in Clinical Attachment Level (CAL)
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Smoking is the major preventable risk factor in the initiation and progression of periodontal diseases. Periodontitis risk was found to be 3.9 times higher among smokers aged between 19-30 years and 2.8 times higher among smokers aged 31-40 years compared to non-smokers. Aggressive periodontitis (AgP), is characterized by a rapid attachment loss usually incompatible with the amount of plaque and dental calculus. It is often not possible to predict the prognosis of treatment with various treatment options in cases of aggressive periodontitis. It was hypothesized that non-smoker patients with generalized aggressive periodontitis (GAgP) will respond better to conventional mechanical non-surgical periodontal therapy compared to the smokers. Therefore, the aim of this study was to evaluate the effects of smoking on the outcomes of non-surgical periodontal treatment in terms of the clinical, biochemical and microbiological parameters.
Investigators
Nurcan Buduneli
Clinical Professor
Ege University
Eligibility Criteria
Inclusion Criteria
- •Having at least six permanent teeth, including incisors and/or first molars with severe periodontal disease
- •Having at least one site with probing depth (PD) and clinical attachment level (CAL) ≥5 mm and six teeth other than first molars and incisors with similar PD and CAL measurements
- •Familial aggregation
Exclusion Criteria
- •Medical disorders such as diabetes mellitus, immunological disorders
- •Having an antibiotic or periodontal treatment in the last 6 months
- •Having \<15 teeth
Outcomes
Primary Outcomes
Change in Clinical Attachment Level (CAL)
Time Frame: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
Secondary Outcomes
- Change in Probing Depth (PD)(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Change in Plaque Index (PI)(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Change in Bleeding on Probing (BoP)(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Changing of the amount of pathogen microorganisms(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Changing of the salivary biomarkers(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Changing of the serum biomarkers(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Changing of the gingival crevicular fluid (GCF) biomarkers(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)