Evaluation, the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Lovastatin in the Preservation of the Tooth Socket

Phase 2

• Conditions: Bone Loss
• Interventions: Drug: Lovastatin 40 MG; Procedure: without drug with Bone graft

• Registration Number: NCT03981601
• Lead Sponsor: Islamic Azad University, Tehran

Brief Summary

Twenty patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which have more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected.

Detailed Description

twenty healthy patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which has more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected. moreover, divided the socket randomly to two groups(A, B)including A: bone graft with lovastatin and B: bone graft alone, after 3 months with trephine will collect the samples. following the histomorphometric analysis.

Study Timeline

• Study Start: 2018-02-22
• Study First Submitted: 2019-02-09
• Primary Completion: 2019-03-30
• Status Verified: 2019-06
• Study First Submitted QC: 2019-06-10
• Last Update Submitted: 2019-06-10
• Study First Posted: 2019-06-11
• Last Update Posted: 2019-06-11
• Study Completion: 2019-07-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. at least 18 years old
2. tooth fracture, root caries
3. Patients are volunteered for placement of the implant

Exclusion Criteria

1. systemic diseases
2. Pregnancy and breastfeeding
3. malignancy, radiation therapy,
4. history of periodontal surgery during the six months ago.
5. medicine(phosphonates, antibiotic,...)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
lovastatin 40 mg with bone graft	Lovastatin 40 MG	after tooth extraction, put teh lovastatin40 mg wif bone graft wifin tooth socket
without drug with bone graft	without drug with Bone graft	after tooth extraction, put the bone graft wifin tooth socket

Primary Outcome Measures

Name	Time	Method
Socket preservation with Lovastatin as evaluated by the amount of bone formation volume	3 month

Trial Locations

Locations (1)

Amirhossein Farahmand; 🇮🇷 Tehran, Iran, Islamic Republic of