the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) With Lovastatin in the Preservation of the Tooth Socket
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Socket preservation with Lovastatin as evaluated by the amount of bone formation volume
研究概览
简要总结
Twenty patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which have more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected.
详细描述
twenty healthy patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which has more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected. moreover, divided the socket randomly to two groups(A, B)including A: bone graft with lovastatin and B: bone graft alone, after 3 months with trephine will collect the samples. following the histomorphometric analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •at least 18 years old
- •tooth fracture, root caries
- •Patients are volunteered for placement of the implant
排除标准
- •systemic diseases
- •Pregnancy and breastfeeding
- •malignancy, radiation therapy,
- •history of periodontal surgery during the six months ago.
- •medicine(phosphonates, antibiotic,...)
研究组 & 干预措施
lovastatin 40 mg with bone graft
after tooth extraction, put teh lovastatin40 mg wif bone graft wifin tooth socket
干预措施: Lovastatin 40 MG (Drug)
without drug with bone graft
after tooth extraction, put the bone graft wifin tooth socket
干预措施: without drug with Bone graft (Procedure)
结局指标
主要结局
Socket preservation with Lovastatin as evaluated by the amount of bone formation volume
时间窗: 3 month
次要结局
未报告次要终点
研究者
Amirhossein Farahmand
assistant prof
Islamic Azad University, Tehran