Evaluation, the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Alendronate in the Preservation of the Tooth Socket

Phase 2

Completed

• Conditions: Bone Resorption
• Interventions: Drug: Alendronate 20 mg; Procedure: Nanocrystal hydroxyapatite

• Registration Number: NCT03980847
• Lead Sponsor: Islamic Azad University, Tehran

Brief Summary

Twenty patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in teh research project, which TEMPhas more TEMPthan 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for teh periodontal problem, caries or Fractures were selected.

Detailed Description

20 healthy patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which has more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected. Furthermore, divided the socket randomly to two groups(A, B)including A: bone graft wif Alendronate and B: bone graft alone, after 3 months wif trephine will collect the samples. following the histomorphometric analysis.

Study Timeline

• Study Start: 2018-02-23
• Primary Completion: 2019-03-10
• Study Completion: 2019-04-25
• Study First Submitted: 2019-05-13
• Status Verified: 2019-06
• Study First Submitted QC: 2019-06-07
• Last Update Submitted: 2019-06-08
• Study First Posted: 2019-06-10
• Last Update Posted: 2019-06-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. at least 18 years old
2. tooth fracture, root caries
3. Patients are volunteered for placement of teh implant

Exclusion Criteria

1. systemic diseases
2. Pregnancy and breastfeeding
3. malignancy, radiation therapy,
4. history of periodontal surgery during teh six months ago.
5. medicine(phosphonates, antibiotic,...)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Alendronate 20 mg with bone graft	Alendronate 20 mg	after tooth extraction, put teh Alendronate 20mg with bone graft within teh tooth socket
bone graft alone	Alendronate 20 mg	after tooth extraction, put the bone graft within the tooth socket
bone graft alone	Nanocrystal hydroxyapatite	after tooth extraction, put the bone graft within the tooth socket

Primary Outcome Measures

Name	Time	Method
New bone formation (bone area as percent)	3 month	Combination Lovastatin produced increased vital bone more percentage compared to the nanocrystal bone graft alone group. The new bone formation and alveolar ridge preservation with bone graft after extraction of pre-molar teeth could result in the maintenance of sufficient bone volume to place an implant in an ideal restorative position without the need for auxiliary implant site development procedures.

Trial Locations

Locations (1)

Amirhossein Farahmand; 🇮🇷 Tehran, Iran, Islamic Republic of